Sickle Cell Disease: Genetics, Cellular and Molecular Mechanisms, and Therapies
نویسندگان
چکیده
منابع مشابه
Sickle Cell Disease: Genetics, Cellular and Molecular Mechanisms, and Therapies
Sickle cell disease (SCD) is a global public health disorder that affects millions of people across the globe. It is a monogenic disorder caused by an A-toT point mutation in the β-globin gene that produces abnormal hemoglobin S (Hb S), which polymerizes in the deoxygenated state, resulting in physical deformation or sickling of erythrocytes. Sickle erythrocytes promote vaso-occlusion and hemol...
متن کاملOxidative Stress in Cardiovascular Pathologies: Genetics, Cellular, and Molecular Mechanisms and Future Antioxidant Therapies
1Department of Genomics, Transcriptomics, and Molecular Therapies, Molecular and Cellular Pharmacology, Functional Genomics Laboratory, Institute of Cellular Biology and Pathology “Nicolae Simionescu,” 8 BP Hasdeu Street, 050568 Bucharest, Romania 2Division of Cardiovascular Sciences, Center for Applied Medical Research, University of Navarra, Pio XII, 31008 Pamplona, Spain 3Vascular Research L...
متن کاملO14: Cellular and Molecular Mechanisms of Spinal Cord Trauma
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملPneumoviruses: Molecular Genetics and Reverse Genetics
Pneumoviruses are responsible for significant respiratory disease in their hosts and represent a major problemfor human and animal health. Pneumoviruses are members of the family Paramyxoviridae, subfamilyPneumovirinae and the virus particles consist of a negative-sense, nonsegmented RNA genome within a helical nucleocapsid structure enveloped in a lipid membrane derived from the ho...
متن کاملNovel therapies in sickle cell disease.
Despite an increased understanding of the pathophysiology of sickle cell disease (SCD), there remains a paucity of available agents for the prevention and treatment of specific SCD-related complications. Recently, there has been significant progress in the development of novel drugs for this disease. These agents, which increase the production of fetal hemoglobin, improve red blood cell hydrati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Anemia
سال: 2012
ISSN: 2090-1267,2090-1275
DOI: 10.1155/2012/143594